Juvenile Laryngeal Paralysis & Polyneuropathy

 

Juvenile Laryngeal Paralysis & Polyneuropathy (JLPP) is a genetic disease that affects the nerves that supply the muscles of of the larynx, leading to muscle weakness and paralysis throughout the spine and body and has recently been discovered in Rottweilers. 


Polyneuropathy: poly- (many), Neuro- (nerves), -Pathy (a disease).
 


Juvenile Laryngeal Paralysis & Polyneuropathy (JLPP) is inherited as autosomal recessive trait. The test enables breeders to identify their dogs as Clear (N/N), Carriers (N/JLPP), or Affected (JLPP/JLPP), and this helps breeders to avoid having affected puppies while maintaining the diversity of the gene pool.

 

Clear

Genotype: N / N [ Homozygous normal ]

The dog is noncarrier of the mutant gene.

It is very unlikely that the dog will develop Juvenile Laryngeal Paralysis & Polyneuropathy (JLPP). The dog will never pass the mutation to its offspring, and therefore it can be bred to any other dog.

 

Carrier

Genotype: N / JLPP [ Heterozygous ]

The dog carries one copy of the mutant gene and one copy of the normal gene.

It is very unlikely that the dog will develop Juvenile Laryngeal Paralysis & Polyneuropathy (JLPP) but since it carries the mutant gene, it can pass it on to its offspring with the probability of 50%.

Carriers should only be bred to clear dogs.

Avoid breeding carrier to carrier because 25% of their offspring is expected to be affected 

 

The truth about Carriers

The carriers are ONLY A CARRIER of the mutant gene. The don't have any symptoms of the disease, nor will they at any stage of their lives and are unaffected by it. They live out a normal, healthy life in every sense of the word. 
 

Mating a CARRIER to a CLEAR is OK

NO AFFECTED pups can result in the litter

 

Affected

Genotype: JLPP / JLPP [ Homozygous mutant ]

The dog carries two copies of the mutant gene and therefore it will pass the mutant gene to its entire offspring.

The dog is likely to develop Juvenile Laryngeal Paralysis & Polyneuropathy (JLPP) and will pass the mutant gene to its entire offspring


Inheritance: AUTOSOMAL RECESSIVE trait;